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SPI 112
CAS No. 1051387-90-6
SPI 112( SPI-112 | SPI112 | SPI 112 )
Catalog No. M17127 CAS No. 1051387-90-6
SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 39 | In Stock |
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| 25MG | 77 | In Stock |
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| 50MG | 135 | In Stock |
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| 100MG | Get Quote | In Stock |
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Biological Information
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Product NameSPI 112
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NoteResearch use only, not for human use.
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Brief DescriptionSPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
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DescriptionSPI-112, the SPI-112 methyl ester analog was able to inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
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In Vitro——
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In Vivo——
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SynonymsSPI-112 | SPI112 | SPI 112
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PathwayOthers
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TargetOther Targets
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RecptorSHP-2
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Research Area——
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Indication——
Chemical Information
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CAS Number1051387-90-6
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Formula Weight468.45
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Molecular FormulaC22H17FN4O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (106.73 mM)
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SMILESO=C(O)c1cccc(N/N=C/2\C(=O)Nc3c2cc(S(=O)(=O)NCc2ccc(F)cc2)cc3)c1
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Chemical Name(Z)-3-(2-(5-(N-(4-Fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chen L, et al. Biochem Pharmacol. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112 . 2010 Sep 15;80(6):801-10
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