SPI 112( SPI-112 | SPI112 | SPI 112 )

Catalog No. M17127 CAS No. 1051387-90-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

SPI 112
Note

Research use only, not for human use.
Brief Description

SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
Description

SPI-112, the SPI-112 methyl ester analog was able to inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
In Vitro

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In Vivo

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Synonyms

SPI-112 | SPI112 | SPI 112
Pathway

Others
Target

Other Targets
Recptor

SHP-2
Research Area

——
Indication

——

CAS Number

1051387-90-6
Formula Weight

468.45
Molecular Formula

C22H17FN4O5S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (106.73 mM)
SMILES

O=C(O)c1cccc(N/N=C/2\C(=O)Nc3c2cc(S(=O)(=O)NCc2ccc(F)cc2)cc3)c1
Chemical Name

(Z)-3-(2-(5-(N-(4-Fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid

1.Chen L, et al. Biochem Pharmacol. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112 . 2010 Sep 15;80(6):801-10

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